Multiple activation pathways of benzene leading to products with varying genotoxic characteristics.
نویسندگان
چکیده
منابع مشابه
Multiple activation pathways of benzene leading to products with varying genotoxic characteristics.
Benzene and 13 potential metabolites were investigated for genotoxicity in Salmonella typhimurium and V79 Chinese hamster cells. In the presence of NADPH-fortified hepatic postmitochondrial fraction (S9 mix), benzene reverted his- S. typhimurium strains. The effect was strongest in strain TA1535. Among the potential metabolites, only the trans-1,2-dihydrodiol, in the presence of S9 mix, and the...
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15 صفحه اولThe Mechanism of Activation of Factor X KINETIC COETROL OF ALTERNATIVE PATHWAYS LEADING TO THE FORMATION
The initial step in the activation of Factor X by a tissue factor-Factor VII complex has been shown to involve hydrolysis of the same peptide bond as is hydrolyzed by Russell’s viper venom. The product, designated a-X&, undergoes autocatalytic conversion to a lower molecular weight form of equal coagulant activity, P-X,. The rate of this conversion is markedly enhanced by phospholipid which is ...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1989
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.898281